Studies on a toxic metabolite from the mould Wallemia.
Food Addit Contam
; 7(1): 69-77, 1990.
Article
in En
| MEDLINE
| ID: mdl-2106458
ABSTRACT
While monitoring the occurrence of toxigenic moulds in foods, using a bioassay screen, it was shown that an isolate of Wallemia sebi produced toxic effects in several of the bioassays. The toxic metabolite was isolated and purified using solvent extraction, TLC and HPLC coupled with the brine shrimp assay to monitor the toxic fractions. The purified toxin, which we propose to call walleminol A, has been partially characterized by mass spectroscopy, nuclear magnetic resonance, ultraviolet and infrared spectroscopy. It can be provisionally interpreted as a tricyclic dihydroxy compound, C15H24O2, with structural features characteristic of a sesquiterpene with an isolated double bond, but further work is required to characterize this compound unequivocally. The minimum inhibitory dose of walleminol A in the bioassays is approximately 50 micrograms/ml, which is comparable with a number of mycotoxins such as citrinin and penicillic acid.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Mitosporic Fungi
/
Mycotoxins
Limits:
Animals
Language:
En
Journal:
Food Addit Contam
Journal subject:
CIENCIAS DA NUTRICAO
Year:
1990
Document type:
Article
Affiliation country:
United kingdom
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM