Effect of immunization on the development of latent ganglionic infection in mice challenged intravaginally with herpes simplex virus types 1 and 2.
Am J Obstet Gynecol
; 131(7): 788-91, 1978 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-210669
ABSTRACT
Immunization of BALB/c mice with virulent and avirulent strains of HSV-1 resulted in high levels of neutralizing antibody and protected against both the lethal effect of the virus and the development of a latent ganglionic infection when animals were challenged by the intravaginal route. In animals immunized with avirulent strain of HSV-2 and challenged with a high virulent strain of HSV-2, substantial protection against death was observed despite low levels of neutralizing antibody. Nineteen per cent of the survivors, however, developed a latent ganglionic infection. Relatively little protection was observed in mice immunized with HSV-1 and challenged with HSV-2.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunization
/
Simplexvirus
/
Ganglia
/
Herpes Simplex
Limits:
Animals
Language:
En
Journal:
Am J Obstet Gynecol
Year:
1978
Document type:
Article