Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence.

Rai, P; Young, J J; Burton, D G A; Giribaldi, M G; Onder, T T; Weinberg, R A

Rai, P; Young, J J; Burton, D G A; Giribaldi, M G; Onder, T T; Weinberg, R A.

Affiliation

Rai P; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami, Miller School of Medicine, Miami, FL 33136, USA. prai@med.miami.edu

Oncogene ; 30(12): 1489-96, 2011 Mar 24.

Article in En | MEDLINE | ID: mdl-21076467

Subject(s)

DNA Damage/genetics; DNA Repair Enzymes/biosynthesis; Genes, ras; Guanine Nucleotides/metabolism; Phosphoric Monoester Hydrolases/biosynthesis; Cell Line; Cell Proliferation; Cellular Senescence/genetics; Humans; Oxidation-Reduction; Reactive Oxygen Species/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Genes, ras / Phosphoric Monoester Hydrolases / DNA Repair Enzymes / Guanine Nucleotides Limits: Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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