Enantioseparation of rabeprazole and omeprazole by nonaqueous capillary electrophoresis with an ephedrine-based ionic liquid as the chiral selector.
Biomed Chromatogr
; 24(12): 1332-7, 2010 Dec.
Article
in En
| MEDLINE
| ID: mdl-21077252
ABSTRACT
An ephedrine-based chiral ionic liquid, (+)-N,N-dimethylephedrinium-bis(trifluoromethanesulfon)imidate ([DMP](+) [Tf(2) N](-) ), served as both chiral selector and background electrolyte in nonaqueous capillary electrophoresis. The enantioseparation of rabeprazole and omeprazole was achieved in acetonitrile-methanol (6040 v/v) containing 60 mm[DMP](+) [Tf(2) N](-) . The influences of separation conditions, including the concentration of [DMP](+) [Tf(2) N](-) , the electrophoretic media and the buffer, on enantioseparation were evaluated. The mechanism of enantioseparation was investigated and discussed. Ion-pair interaction and hydrogen bonding may be responsible for the main separation mechanism.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Omeprazole
/
Electrophoresis, Capillary
/
Ephedrine
/
2-Pyridinylmethylsulfinylbenzimidazoles
Type of study:
Evaluation_studies
Language:
En
Journal:
Biomed Chromatogr
Year:
2010
Document type:
Article
Affiliation country:
China