Inhibition of the inflammatory cytokine TNF-&#945; increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression.

Salako, Michael A; Kulbe, Hagen; Ingemarsdotter, Carin K; Pirlo, Katrina J; Williams, Sarah L; Lockley, Michelle; Balkwill, Frances R; McNeish, Iain A

Inhibition of the inflammatory cytokine TNF-α increases adenovirus activity in ovarian cancer via modulation of cIAP1/2 expression.

Salako, Michael A; Kulbe, Hagen; Ingemarsdotter, Carin K; Pirlo, Katrina J; Williams, Sarah L; Lockley, Michelle; Balkwill, Frances R; McNeish, Iain A.

Affiliation

Salako MA; Centres for Molecular Oncology and Imaging, Institute of Cancer, Barts and The London School of Medicine and Dentistry, London, UK.

Mol Ther ; 19(3): 490-9, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21081903

Subject(s)

Adenoviridae; Inhibitor of Apoptosis Proteins/metabolism; Oncolytic Viruses; Ovarian Neoplasms; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Tumor Necrosis Factor-alpha/metabolism; Adenoviridae/drug effects; Adenoviridae/immunology; Adenoviridae/metabolism; Animals; Antibodies, Monoclonal/pharmacology; Apoptosis/drug effects; Apoptosis/genetics; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic/drug effects; Gene Expression Regulation, Neoplastic/genetics; Gene Knockdown Techniques; Humans; Infliximab; Mice; Mice, Inbred BALB C; Mice, Nude; Oncolytic Virotherapy; Oncolytic Viruses/drug effects; Oncolytic Viruses/immunology; Oncolytic Viruses/metabolism; Ovarian Neoplasms/metabolism; Ovarian Neoplasms/pathology; Ovarian Neoplasms/therapy; Ovarian Neoplasms/virology; RNA, Small Interfering/genetics; RNA, Small Interfering/metabolism; Survival Analysis; Tumor Necrosis Factor-alpha/pharmacology; Virus Replication/drug effects; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Adenoviridae / Tumor Necrosis Factor-alpha / Oncolytic Viruses / Inhibitor of Apoptosis Proteins Type of study: Prognostic_studies Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2011 Document type: Article Affiliation country: United kingdom

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