Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome.
Euro Surveill
; 15(43)2010 Oct 28.
Article
in En
| MEDLINE
| ID: mdl-21087581
ABSTRACT
Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating in Italy were examined, focusing on amino acid changes at position 222 because of its suggested pathogenic relevance. Among 169 patients, the D222G substitution was detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mild cases, whereas the D222E mutation was more frequent and evenly distributed in mild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among school children confirms reported human-to-human transmission of viruses mutated at amino acid position 222.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amino Acid Substitution
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
/
Pandemics
/
Hemagglutinins
Type of study:
Risk_factors_studies
/
Screening_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
Euro Surveill
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2010
Document type:
Article
Affiliation country:
Italy