Modulation of neurotransmitter receptors and synaptic differentiation by proteins containing complement-related domains.
Neurosci Res
; 69(2): 87-92, 2011 Feb.
Article
in En
| MEDLINE
| ID: mdl-21093502
Neurotransmitter receptors play central roles in basic neurotransmission and synaptic plasticity. Recent studies have revealed that some transmembrane and extracellular proteins bind to neurotransmitter receptors, forming protein complexes that are required for proper synaptic localization or gating of core receptor molecules. Consequently, the components of these complexes contribute to long-term potentiation, a process that is critical for learning and memory. Here, we review factors that regulate neurotransmitter receptors, with a focus on proteins containing CUB (complement C1r/C1s, Uegf, Bmp1) or CCP (complement control protein) domains, which are frequently found in complement system proteins. Proteins that contain these domains are structurally distinct from TARPs (transmembrane AMPA receptor regulatory proteins), and may constitute new protein families that modulate either the localization or function of neurotransmitter receptors. In addition, other CCP domain-containing proteins participate in dendritic patterning and/or synaptic differentiation, although current evidence has not identified any direct activities on neurotransmitter receptors. Some of these proteins are involved in pathologic conditions such as epileptic seizure and mental retardation. Together, these lines of information have shown that CUB and CCP domain-containing proteins contribute to a wide variety of neuronal events that ultimately establish neural circuits.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synapses
/
Cell Differentiation
/
Receptors, Neurotransmitter
/
Synaptic Transmission
/
Neuronal Plasticity
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurosci Res
Journal subject:
NEUROLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Japan
Country of publication:
Ireland