Contribution of epithelial plasticity to renal transplantation-associated fibrosis.
Transplant Proc
; 42(9 Suppl): S7-12, 2010 Nov.
Article
in En
| MEDLINE
| ID: mdl-21095454
ABSTRACT
Every year in the United States, 5000 renal transplant recipients start or restart dialysis because of the unusual propensity of these allografts to develop interstitial fibrosis and tubular atrophy (IF/TA). Although IF/TA often follows one or more identifiable events, our capacity to specifically treat, prevent, or even detect IF/TA at an early stage is poor. These limitations are largely related to our lack of adequate tools to assess graft failure over time. Data accumulated over the past 5 years have demonstrated that tubular epithelial cells may react to certain fibrogenic stimuli to engage in the process of epithelial-to-mesenchymal transition (EMT). In this review, we highlight the current view of EMT with a focus on both its role in the context of renal transplantation and the potential for utilizing markers of EMT to identify patients undergoing early IF/TA.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Kidney Transplantation
/
Epithelial Cells
/
Epithelial-Mesenchymal Transition
/
Kidney Diseases
/
Kidney Tubules
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Transplant Proc
Year:
2010
Document type:
Article
Affiliation country:
United States