L-662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals.

Sugrue, M F; Gautheron, P; Mallorga, P; Nolan, T E; Graham, S L; Schwam, H; Shepard, K L; Smith, R L

Sugrue, M F; Gautheron, P; Mallorga, P; Nolan, T E; Graham, S L; Schwam, H; Shepard, K L; Smith, R L.

Affiliation

Sugrue MF; Merck Sharp & Dohme Research Laboratories, West Point, PA 19486.

Br J Pharmacol ; 99(1): 59-64, 1990 Jan.

Article in En | MEDLINE | ID: mdl-2110013

Subject(s)

Carbonic Anhydrase Inhibitors/pharmacology; Intraocular Pressure/drug effects; Sulfonamides/pharmacology; Thiophenes/pharmacology; Administration, Topical; Animals; Aqueous Humor/enzymology; Carbonic Anhydrase Inhibitors/administration & dosage; Carbonic Anhydrases/metabolism; Ciliary Body/enzymology; Eye/drug effects; Eye/enzymology; Female; In Vitro Techniques; Iris/enzymology; Macaca fascicularis; Male; Rabbits; Sulfonamides/administration & dosage; Thiophenes/administration & dosage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Thiophenes / Carbonic Anhydrase Inhibitors / Intraocular Pressure Type of study: Prognostic_studies Limits: Animals Language: En Journal: Br J Pharmacol Year: 1990 Document type: Article Country of publication: United kingdom

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