Chemical switch of a metabotropic glutamate receptor 2 silent allosteric modulator into dual metabotropic glutamate receptor 2/3 negative/positive allosteric modulators.

Schann, Stephan; Mayer, Stanislas; Franchet, Christel; Frauli, Mélanie; Steinberg, Edith; Thomas, Mireille; Baron, Luc; Neuville, Pascal

Schann, Stephan; Mayer, Stanislas; Franchet, Christel; Frauli, Mélanie; Steinberg, Edith; Thomas, Mireille; Baron, Luc; Neuville, Pascal.

Affiliation

Schann S; Domain Therapeutics SA, Bioparc, Boulevard Sebastien Brant, F-67400 Strasbourg-Illkirch, France. sschann@domaintherapeutics

J Med Chem ; 53(24): 8775-9, 2010 Dec 23.

Article in En | MEDLINE | ID: mdl-21105727

Subject(s)

Benzopyrans/chemical synthesis; Excitatory Amino Acid Agents/chemical synthesis; Receptors, Metabotropic Glutamate/physiology; Allosteric Regulation; Benzopyrans/chemistry; Benzopyrans/pharmacology; Calcium/metabolism; Cell Line; Excitatory Amino Acid Agents/chemistry; Excitatory Amino Acid Agents/pharmacology; Fluorescence Resonance Energy Transfer; High-Throughput Screening Assays; Humans; Small Molecule Libraries; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzopyrans / Receptors, Metabotropic Glutamate / Excitatory Amino Acid Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2010 Document type: Article Affiliation country: France Country of publication: United States

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