COMP-Ang1, a variant of angiopoietin 1, inhibits serum-deprived apoptosis of mesenchymal cells via PI3K/Akt and mitogen-activated protein kinase pathways.

Lee, Kkot-Nim; Seo, Min-Chul; Bae, In-Ho; Oh, Sin-Hye; Jang, Won Gu; Jeong, Byung-Chul; Oh, Won-Mann; Kim, Sun-Hun; Lee, Shee-Eun; Shim, Kyung Mi; Park, Bae-Keun; Koh, Jeong-Tae

Lee, Kkot-Nim; Seo, Min-Chul; Bae, In-Ho; Oh, Sin-Hye; Jang, Won Gu; Jeong, Byung-Chul; Oh, Won-Mann; Kim, Sun-Hun; Lee, Shee-Eun; Shim, Kyung Mi; Park, Bae-Keun; Koh, Jeong-Tae.

Affiliation

Lee KN; Dental Science Research Institute and the BK21 Project, School of Dentistry, Chonnam National University, Republic of Korea.

Pharmacology ; 86(5-6): 327-35, 2010.

Article in En | MEDLINE | ID: mdl-21109762

Subject(s)

Apoptosis/drug effects; Mesenchymal Stem Cells/drug effects; Recombinant Fusion Proteins/pharmacology; Animals; Blotting, Western; Cell Survival/drug effects; Cells, Cultured; Cyclin D1/genetics; Humans; Mesenchymal Stem Cells/metabolism; Mice; Mitogen-Activated Protein Kinases/metabolism; Phosphatidylinositol 3-Kinase/metabolism; Proto-Oncogene Proteins c-akt/metabolism; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Apoptosis / Mesenchymal Stem Cells Limits: Animals / Humans Language: En Journal: Pharmacology Year: 2010 Document type: Article Country of publication: Switzerland

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