Neuroprotective properties of afobazole in repeated hemorrhagic stroke modeling in aged rats.

Kraineva, V A; Seredenin, S B

Kraineva, V A; Seredenin, S B.

Affiliation

Kraineva VA; V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Russia. niipharm@mail.ru

Bull Exp Biol Med ; 149(2): 204-7, 2010 Aug.

Article in En, Ru | MEDLINE | ID: mdl-21113492

ABSTRACT

ABSTRACT

Intraperitoneal administration of afobazole in a dose of 0.1 mg/kg over 2 weeks after repeated modeling of intracerebral post-traumatic hematoma reduces animal mortality, decreases motor coordination disturbances, and improves learning and memory processes in rats.

Subject(s)

Ataxia/drug therapy; Benzimidazoles/pharmacology; Cerebral Hemorrhage, Traumatic/drug therapy; Learning/drug effects; Memory/drug effects; Morpholines/pharmacology; Neuroprotective Agents/pharmacology; Age Factors; Animals; Ataxia/etiology; Benzimidazoles/administration & dosage; Benzimidazoles/therapeutic use; Cerebral Hemorrhage, Traumatic/complications; Cerebral Hemorrhage, Traumatic/mortality; Injections, Intraperitoneal; Male; Morpholines/administration & dosage; Morpholines/therapeutic use; Neuroprotective Agents/administration & dosage; Neuroprotective Agents/therapeutic use; Rats

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Collection: 01-internacional Database: MEDLINE Main subject: Ataxia / Benzimidazoles / Morpholines / Neuroprotective Agents / Cerebral Hemorrhage, Traumatic / Learning / Memory Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En / Ru Journal: Bull Exp Biol Med Year: 2010 Document type: Article Affiliation country: RUSSIA

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