Transgenic &#945;-1-antitrypsin secreted into the bloodstream from salivary glands is biologically active.

Perez, P; Adriaansen, J; Goldsmith, C M; Zheng, C; Baum, B J

Transgenic α-1-antitrypsin secreted into the bloodstream from salivary glands is biologically active.

Perez, P; Adriaansen, J; Goldsmith, C M; Zheng, C; Baum, B J.

Affiliation

Perez P; Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-1190, USA. perezriverosp@mail.nih.gov

Oral Dis ; 17(5): 476-83, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21122036

Subject(s)

Gene Transfer Techniques; Serine Proteinase Inhibitors/genetics; Submandibular Gland/enzymology; alpha 1-Antitrypsin/genetics; Adenoviridae/genetics; Animals; Cell Line; Genetic Vectors/genetics; Glycoside Hydrolases/pharmacology; Glycosylation/drug effects; Humans; Immunohistochemistry; Leukocyte Elastase/antagonists & inhibitors; Male; Mice; Mice, Inbred BALB C; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/pharmacology; Plasmids/genetics; Rats; Rats, Wistar; Saliva/enzymology; Serine Proteinase Inhibitors/analysis; Serine Proteinase Inhibitors/blood; Submandibular Gland/cytology; Submandibular Gland/metabolism; Tissue Extracts/analysis; alpha 1-Antitrypsin/analysis; alpha 1-Antitrypsin/blood

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Submandibular Gland / Serine Proteinase Inhibitors / Alpha 1-Antitrypsin / Gene Transfer Techniques Limits: Animals / Humans / Male Language: En Journal: Oral Dis Journal subject: ODONTOLOGIA Year: 2011 Document type: Article Affiliation country: United States Country of publication: Denmark

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