Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase.

Taricani, Lorena; Shanahan, Frances; Pierce, Rob H; Guzi, Timothy J; Parry, David

Taricani, Lorena; Shanahan, Frances; Pierce, Rob H; Guzi, Timothy J; Parry, David.

Affiliation

Taricani L; Merck Research Laboratory, Palo Alto, CA, USA.

Cell Cycle ; 9(24): 4876-83, 2010 Dec 15.

Article in En | MEDLINE | ID: mdl-21131780

Subject(s)

DNA Glycosylases/metabolism; Thymidylate Synthase/antagonists & inhibitors; Biomarkers/metabolism; Cell Line; Checkpoint Kinase 1; DNA Glycosylases/genetics; DNA Repair; Enzyme Inhibitors/metabolism; Folic Acid Antagonists/metabolism; Histones/genetics; Histones/metabolism; Humans; Methotrexate/metabolism; Nucleic Acid Synthesis Inhibitors/metabolism; Phenotype; Protein Kinases/genetics; Protein Kinases/metabolism; Quinazolines/metabolism; Thiophenes/metabolism; Thymidylate Synthase/genetics; Thymidylate Synthase/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Thymidylate Synthase / DNA Glycosylases Limits: Humans Language: En Journal: Cell Cycle Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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