Pyruvate promotes tumor angiogenesis through HIF-1-dependent PAI-1 expression.

Jung, Seung-Youn; Song, Hyun Seok; Park, Shi-Young; Chung, Soo-Hak; Kim, Yung-Jin

Jung, Seung-Youn; Song, Hyun Seok; Park, Shi-Young; Chung, Soo-Hak; Kim, Yung-Jin.

Affiliation

Jung SY; Department of Molecular Biology, College of Natural Science, Pusan National University, Busan 609-735, Republic of Korea.

Int J Oncol ; 38(2): 571-6, 2011 Feb.

Article in En | MEDLINE | ID: mdl-21132271

Subject(s)

Carcinoma, Hepatocellular/blood supply; Carcinoma, Hepatocellular/drug therapy; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Neovascularization, Pathologic; Plasminogen Activator Inhibitor 1/genetics; Pyruvic Acid/pharmacology; Blotting, Western; Carcinoma, Hepatocellular/pathology; Cells, Cultured; Electrophoretic Mobility Shift Assay; Endothelium, Vascular/cytology; Endothelium, Vascular/drug effects; Endothelium, Vascular/metabolism; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Liver Neoplasms/blood supply; Liver Neoplasms/drug therapy; Liver Neoplasms/pathology; Plasminogen Activator Inhibitor 1/metabolism; Promoter Regions, Genetic/drug effects; Promoter Regions, Genetic/genetics; RNA, Messenger/genetics; Response Elements/physiology; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic/drug effects; Umbilical Veins/cytology; Umbilical Veins/drug effects; Umbilical Veins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasminogen Activator Inhibitor 1 / Carcinoma, Hepatocellular / Pyruvic Acid / Hypoxia-Inducible Factor 1, alpha Subunit / Neovascularization, Pathologic Limits: Humans Language: En Journal: Int J Oncol Journal subject: NEOPLASIAS Year: 2011 Document type: Article

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