Impact of CCR5delta32 host genetic background and disease progression on HIV-1 intrahost evolutionary processes: efficient hypothesis testing through hierarchical phylogenetic models.

Edo-Matas, Diana; Lemey, Philippe; Tom, Jennifer A; Serna-Bolea, Cèlia; van den Blink, Agnes E; van 't Wout, Angélique B; Schuitemaker, Hanneke; Suchard, Marc A

Edo-Matas, Diana; Lemey, Philippe; Tom, Jennifer A; Serna-Bolea, Cèlia; van den Blink, Agnes E; van 't Wout, Angélique B; Schuitemaker, Hanneke; Suchard, Marc A.

Affiliation

Edo-Matas D; Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, Center for Infection and Immunity Amsterdam at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.

Mol Biol Evol ; 28(5): 1605-16, 2011 May.

Article in En | MEDLINE | ID: mdl-21135151

Subject(s)

Evolution, Molecular; Gene Deletion; HIV Infections/genetics; HIV-1/genetics; Models, Genetic; Receptors, CCR5/genetics; Acquired Immunodeficiency Syndrome/genetics; Acquired Immunodeficiency Syndrome/physiopathology; Acquired Immunodeficiency Syndrome/virology; Bayes Theorem; CD4 Lymphocyte Count; Disease Progression; Genotype; HIV Envelope Protein gp120/genetics; HIV Infections/physiopathology; HIV Infections/virology; HIV-1/isolation & purification; Heterozygote; Host-Pathogen Interactions; Humans; Male; Phylogeny; Polymorphism, Genetic; Sequence Alignment; Sequence Analysis, DNA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / HIV-1 / Gene Deletion / Evolution, Molecular / Receptors, CCR5 / Models, Genetic Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Mol Biol Evol Journal subject: BIOLOGIA MOLECULAR Year: 2011 Document type: Article Affiliation country: Netherlands Country of publication: United States

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