Carotid Stenosis/prevention & control; Cell Movement/drug effects; Down-Regulation/drug effects; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular/drug effects; Piperazines/pharmacology; Pyridines/pharmacology; Receptor, PAR-1/antagonists & inhibitors; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Animals; Carotid Stenosis/metabolism; Cell Movement/physiology; Cell Proliferation/drug effects; Cells, Cultured; Coronary Restenosis/drug therapy; Coronary Restenosis/metabolism; Down-Regulation/physiology; Gene Expression Regulation, Enzymologic; Humans; Male; Matrix Metalloproteinase 7/biosynthesis; Muscle, Smooth, Vascular/enzymology; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/drug effects; Myocytes, Smooth Muscle/enzymology; Myocytes, Smooth Muscle/metabolism; Piperazines/therapeutic use; Pyridines/therapeutic use; Rats; Rats, Sprague-Dawley; Receptor, PAR-1/physiology; Tumor Necrosis Factor-alpha/metabolism