Pd-catalyzed cross-coupling of α-(acyloxy)-tri-n-butylstannanes with alkenyl, aryl, and heteroaryl electrophiles.
Org Lett
; 13(2): 344-6, 2011 Jan 21.
Article
in En
| MEDLINE
| ID: mdl-21141984
ABSTRACT
Racemic and scalemic α-(acyloxy)-tri-n-butylstannanes undergo Pd-catalyzed cross-couplings with alkenyl/aryl/heteroaryl iodides, bromides, and triflates in moderate to good yields in THF at 45 °C. Simple aryl iodides and unprotected aza-arenes, two classes of electrophiles that typically react sluggishly, are also good substrates. Cross-couplings proceed with retention of configuration at the alkenyl and stannyl-substituted stereocenters.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palladium
/
Trialkyltin Compounds
/
Hydrocarbons, Brominated
/
Hydrocarbons, Iodinated
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2011
Document type:
Article
Affiliation country:
United States