Early detection of renal damage caused by fumaric acid ester therapy by determination of urinary ß2-microglobulin.
Br J Dermatol
; 164(3): 648-51, 2011 Mar.
Article
in En
| MEDLINE
| ID: mdl-21143462
ABSTRACT
BACKGROUND:
Fumaric acid esters are considered efficacious and safe drugs for the treatment of psoriasis. Renal damage, caused either by acute renal injury or Fanconi syndrome, is a recognized side-effect of this therapy.OBJECTIVES:
To investigate whether the measurement of urinary excretion of ß2-microglobulin, a marker of renal proximal tubular dysfunction, allows early detection of kidney damage before an increase in serum creatinine or significant proteinuria occurs.METHODS:
Urinary ß2-microglobulin excretion was measured regularly in 23 patients undergoing fumaric acid ester therapy.RESULTS:
Urinary ß2-microglobulin remained normal in all 10 male patients. Three (23%) out of 13 female patients experienced an increase in urinary ß2-microglobulin excretion. In two of these patients a sharp increase was observed in association with high doses. One further patient had moderately elevated levels on rather low doses of fumaric acid esters. After discontinuing treatment, urinary ß2-microglobulin levels returned to normal within a few weeks.CONCLUSION:
Determination of urinary ß2-microglobulin possibly allows early detection of renal damage by fumaric acid esters. Female patients seem to be prone to this side-effect, especially when taking high doses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Beta 2-Microglobulin
/
Acute Kidney Injury
/
Fumarates
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Br J Dermatol
Year:
2011
Document type:
Article
Affiliation country:
Austria