Hormonal contraceptives and the length of their use are not independent risk factors for high-risk HPV infections or high-grade CIN.
Gynecol Obstet Invest
; 71(2): 93-103, 2011.
Article
in En
| MEDLINE
| ID: mdl-21150159
ABSTRACT
AIMS:
To evaluate the role of hormonal contraceptives as a risk factor of high-risk human papillomavirus (HR-HPV), cervical intraepithelial lesions (CIN) and cervical cancer in our multi-center population-based LAMS (Latin American Screening) study.METHODS:
A cohort study with >12,000 women from Brazil and Argentina using logistic regression to analyze the covariates of hormonal contraception (HOC - oral, injections, patches, implants, vaginal ring and progesterone intrauterine system) use followed by multivariate modeling for predictors of HR-HPV and CIN2+.RESULTS:
HR-HPV infection was a consistent risk factor of high-grade CIN in all three groups of women. The length of HOC use was not significantly related to high-grade squamous intraepithelial lesions (HSIL)+ Pap (p = 0.069), LSIL+ Pap (p = 0.781) or ASCUS+ (p = 0.231). The same was true with the length of HOC use and histology CIN3+ (p = 0.115) and CIN2+ (p = 0.515). Frequently, HOC users have previously shown more HPV-related lesions, as well as lower HPV prevalence if they were current smokers. But HOC use and time of usage were not independent risk factors of either HR-HPV infection or high-grade CIN using multiple logistic regressions.CONCLUSIONS:
No evidence was found for an association between the use of HOC with an increased risk for HR-HPV infection or high-grade CIN in this cohort.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uterine Cervical Dysplasia
/
Uterine Cervical Neoplasms
/
Contraception
/
Papillomavirus Infections
Type of study:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Country/Region as subject:
America do sul
/
Argentina
/
Brasil
Language:
En
Journal:
Gynecol Obstet Invest
Year:
2011
Document type:
Article
Affiliation country:
Portugal
Publication country:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND