Neuronal LRP1 knockout in adult mice leads to impaired brain lipid metabolism and progressive, age-dependent synapse loss and neurodegeneration.

Liu, Qiang; Trotter, Justin; Zhang, Juan; Peters, Melinda M; Cheng, Hua; Bao, Jianxin; Han, Xianlin; Weeber, Edwin J; Bu, Guojun

Liu, Qiang; Trotter, Justin; Zhang, Juan; Peters, Melinda M; Cheng, Hua; Bao, Jianxin; Han, Xianlin; Weeber, Edwin J; Bu, Guojun.

Affiliation

Liu Q; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

J Neurosci ; 30(50): 17068-78, 2010 Dec 15.

Article in En | MEDLINE | ID: mdl-21159977

Subject(s)

Lipid Metabolism/genetics; Low Density Lipoprotein Receptor-Related Protein-1/genetics; Nerve Degeneration/metabolism; Neurons/pathology; Prosencephalon/metabolism; Synapses/pathology; Age Factors; Amnesia/pathology; Animals; Cell Culture Techniques; Dendritic Spines/pathology; Hippocampus/metabolism; Low Density Lipoprotein Receptor-Related Protein-1/metabolism; Mice; Mice, Knockout; Nerve Degeneration/genetics; Nerve Degeneration/pathology; Neurons/metabolism; Prosencephalon/pathology; Receptors, AMPA/biosynthesis; Receptors, N-Methyl-D-Aspartate/biosynthesis; Synapses/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Prosencephalon / Low Density Lipoprotein Receptor-Related Protein-1 / Lipid Metabolism / Nerve Degeneration / Neurons Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Neurosci Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

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