Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences.

Amit, Doron; Hochberg, Abraham

Amit, Doron; Hochberg, Abraham.

Affiliation

Amit D; The Hebrew University of Jerusalem, Biological Chemistry, Jerusalem 91904, Israel. dyamit@gmail.com

J Transl Med ; 8: 134, 2010 Dec 16.

Article in En | MEDLINE | ID: mdl-21162716

Subject(s)

Diphtheria Toxin/metabolism; Insulin-Like Growth Factor II/genetics; Peptide Fragments/metabolism; Plasmids/genetics; Promoter Regions, Genetic; RNA, Untranslated/genetics; Urinary Bladder Neoplasms/therapy; Administration, Intravesical; Animals; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Genetic Vectors/administration & dosage; Humans; In Situ Hybridization; Insulin-Like Growth Factor II/metabolism; Luciferases/genetics; Mice; Mice, Nude; RNA, Long Noncoding; RNA, Untranslated/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Subcutaneous Tissue/pathology; Urinary Bladder Neoplasms/genetics; Urinary Bladder Neoplasms/pathology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Plasmids / Urinary Bladder Neoplasms / Insulin-Like Growth Factor II / Promoter Regions, Genetic / RNA, Untranslated / Diphtheria Toxin Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Transl Med Year: 2010 Document type: Article Affiliation country: Israel Country of publication: United kingdom

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