Isolation of a novel neutralizing antibody fragment against human vascular endothelial growth factor from a phage-displayed human antibody repertoire using an epitope disturbing strategy.

Lamdan, Humberto; Ayala, Marta; Rojas, Gertrudis; Munoz, Yasmiana; Morera, Yanelys; Guirola, Osmany; Chinea, Glay; Gavilondo, Jorge V

Lamdan, Humberto; Ayala, Marta; Rojas, Gertrudis; Munoz, Yasmiana; Morera, Yanelys; Guirola, Osmany; Chinea, Glay; Gavilondo, Jorge V.

Affiliation

Lamdan H; Recombinant Antibodies Laboratory, Cancer Research Department, Center for Genetic Engineering and Biotechnology, La Habana, CP 10600, Cuba. humberto.lamdan@cigb.edu.cu

J Biotechnol ; 151(2): 166-74, 2011 Jan 20.

Article in En | MEDLINE | ID: mdl-21167224

Subject(s)

Antibodies, Neutralizing/chemistry; Antibodies/chemistry; Epitopes/chemistry; Vascular Endothelial Growth Factor A/metabolism; Antibodies, Monoclonal/chemistry; Antibodies, Monoclonal, Humanized; Antigens/chemistry; Bevacizumab; Endothelial Cells/cytology; Humans; Immunoglobulin Fragments/chemistry; Mutation; Neovascularization, Physiologic; Peptide Library; Umbilical Veins/cytology; Vascular Endothelial Growth Factor A/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vascular Endothelial Growth Factor A / Antibodies, Neutralizing / Antibodies / Epitopes Limits: Humans Language: En Journal: J Biotechnol Journal subject: BIOTECNOLOGIA Year: 2011 Document type: Article Affiliation country: Cuba

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