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The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma.
Bishop, Erin A; Lengyel, Ernst R; Yamada, S Diane; Montag, Anthony; Temkin, Sarah M.
Affiliation
  • Bishop EA; Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, The University of Chicago Medical Center, Chicago, IL, USA.
Gynecol Oncol ; 121(1): 218-23, 2011 Apr.
Article in En | MEDLINE | ID: mdl-21168200
OBJECTIVE: The hepatocyte growth factor (HGF) receptor c-Met plays an important role in tumor dissemination by activating mitogenic signaling pathways. The goal of this study was to investigate immunohistochemical (IHC) staining patterns of HGF and c-Met in endometrioid endometrial cancer (EC) and uterine serous cancer (USC) and to correlate staining with patient outcomes. METHODS: A tissue microarray was created using tissue from patients with atrophic endometrium (AE), grade 1 EC, grade 3 EC, and USC. Immunohistochemistry was used to detect c-Met, phosphorylated c-Met (p-c-Met), and HGF expression. Differences between IHC staining intensity were calculated using t-tests. Correlations between staining and clinicopathologic variables were determined by Chi-square testing for categorical variables and t-tests for continuous variables. Kaplan-Meier curves were constructed to analyze survival in USC. RESULTS: Patients with cancer had more total c-Met and HGF expression than those with AE (p=0.037, p<0.001 respectively), but no difference in p-c-Met staining. Total c-Met and HGF staining was significantly different between groups (p=0.042, p<0.001 respectively). This difference was accounted for by greater c-MET expression in USC compared to AE (p=0.027). Depth of invasion, stage, and lymph node status were not significantly related to staining intensity. Patients with strong c-Met and HGF staining had decreased overall survival compared to patients with weaker staining. CONCLUSIONS: HGF and c-Met may play a role in the progression of endometrial cancer and should be studied further as prognostic and therapeutic tools.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Neoplasms / Hepatocyte Growth Factor / Receptor Protein-Tyrosine Kinases / Cystadenocarcinoma, Serous Type of study: Prognostic_studies Limits: Aged / Female / Humans / Middle aged Language: En Journal: Gynecol Oncol Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uterine Neoplasms / Hepatocyte Growth Factor / Receptor Protein-Tyrosine Kinases / Cystadenocarcinoma, Serous Type of study: Prognostic_studies Limits: Aged / Female / Humans / Middle aged Language: En Journal: Gynecol Oncol Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States