Bioanalytical method development and validation of natamycin in rabbit tears and its application to ocular pharmacokinetic studies.

Bhatta, R S; Chandasana, H; Rathi, C; Kumar, D; Chhonker, Y S; Jain, G K

Bhatta, R S; Chandasana, H; Rathi, C; Kumar, D; Chhonker, Y S; Jain, G K.

Affiliation

Bhatta RS; Pharmacokinetics and Metabolism Division, Central drug Research Institute, CSIR, Lucknow 226001, India. rabi.cdri@gmail.com

J Pharm Biomed Anal ; 54(5): 1096-100, 2011 Apr 05.

Article in En | MEDLINE | ID: mdl-21168297

Subject(s)

Antifungal Agents/analysis; Antifungal Agents/pharmacokinetics; Drug Monitoring/methods; Natamycin/analysis; Natamycin/pharmacokinetics; Tears/chemistry; Amphotericin B; Animals; Antifungal Agents/administration & dosage; Chromatography, High Pressure Liquid/methods; Dose-Response Relationship, Drug; Drug Stability; Molecular Structure; Natamycin/administration & dosage; Ophthalmic Solutions; Rabbits; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry/methods; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tears / Natamycin / Drug Monitoring / Antifungal Agents Limits: Animals Language: En Journal: J Pharm Biomed Anal Year: 2011 Document type: Article Affiliation country: India

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