Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.

Mo, SangJoon; Kim, Dong Hwan; Lee, Jong Hyun; Park, Je Won; Basnet, Devi B; Ban, Yeon Hee; Yoo, Young Ji; Chen, Shu-wei; Park, Sung Ryeol; Choi, Eun Ae; Kim, Eunji; Jin, Ying-Yu; Lee, Sung-Kwon; Park, Ju Yeol; Liu, Yuan; Lee, Mi Ok; Lee, Keum Soon; Kim, Sang Jun; Kim, Dooil; Park, Byoung Chul; Lee, Sang-gi; Kwon, Ho Jeong; Suh, Joo-Won; Moore, Bradley S; Lim, Si-Kyu; Yoon, Yeo Joon

Mo, SangJoon; Kim, Dong Hwan; Lee, Jong Hyun; Park, Je Won; Basnet, Devi B; Ban, Yeon Hee; Yoo, Young Ji; Chen, Shu-wei; Park, Sung Ryeol; Choi, Eun Ae; Kim, Eunji; Jin, Ying-Yu; Lee, Sung-Kwon; Park, Ju Yeol; Liu, Yuan; Lee, Mi Ok; Lee, Keum Soon; Kim, Sang Jun; Kim, Dooil; Park, Byoung Chul; Lee, Sang-gi; Kwon, Ho Jeong; Suh, Joo-Won; Moore, Bradley S; Lim, Si-Kyu; Yoon, Yeo Joon.

Affiliation

Mo S; Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Republic of Korea.

J Am Chem Soc ; 133(4): 976-85, 2011 Feb 02.

Article in En | MEDLINE | ID: mdl-21175203

Subject(s)

Malonyl Coenzyme A/biosynthesis; Malonyl Coenzyme A/chemistry; Polyketide Synthases/metabolism; Sequence Deletion; Tacrolimus/analogs & derivatives; Tacrolimus/metabolism; Malonyl Coenzyme A/metabolism; Multigene Family; Streptomyces/enzymology; Streptomyces/genetics; Streptomyces/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tacrolimus / Sequence Deletion / Polyketide Synthases / Malonyl Coenzyme A Language: En Journal: J Am Chem Soc Year: 2011 Document type: Article

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