Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor.

Kolte, D; Bryant, Jw; Holsworth, D; Wang, J; Akbari, P; Gibson, Gw; Shariat-Madar, Z

Kolte, D; Bryant, Jw; Holsworth, D; Wang, J; Akbari, P; Gibson, Gw; Shariat-Madar, Z.

Affiliation

Kolte D; Department of Pharmacology, School of Pharmacy, University of Mississippi, University, MS, USA CVMED Exploratory, Pfizer Global Research and Development, Groton, CT, USA.

Br J Pharmacol ; 162(7): 1639-49, 2011 Apr.

Article in En | MEDLINE | ID: mdl-21175583

Subject(s)

Aminobenzoates/pharmacology; Aminopyridines/pharmacology; Enzyme Inhibitors/pharmacology; Plasma Kallikrein/antagonists & inhibitors; Animals; Bradykinin/metabolism; Cells, Cultured; Endothelial Cells/drug effects; Endothelial Cells/enzymology; Endothelial Cells/metabolism; Epoprostenol/metabolism; Humans; Inflammation/drug therapy; Inflammation/enzymology; Kinetics; Kininogen, High-Molecular-Weight/antagonists & inhibitors; Kininogen, High-Molecular-Weight/metabolism; Lipopolysaccharides/pharmacology; Muscle Contraction/drug effects; Nitric Oxide/metabolism; Phenylephrine/metabolism; Phenylephrine/pharmacology; Plasma Kallikrein/chemistry; Plasma Kallikrein/metabolism; Rats; Signal Transduction/drug effects; Substrate Specificity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasma Kallikrein / Enzyme Inhibitors / Aminobenzoates / Aminopyridines Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Br J Pharmacol Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

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