Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts.

Rangaswami, Hema; Schwappacher, Raphaela; Marathe, Nisha; Zhuang, Shunhui; Casteel, Darren E; Haas, Bodo; Chen, Yong; Pfeifer, Alexander; Kato, Hisashi; Shattil, Sanford; Boss, Gerry R; Pilz, Renate B

Rangaswami, Hema; Schwappacher, Raphaela; Marathe, Nisha; Zhuang, Shunhui; Casteel, Darren E; Haas, Bodo; Chen, Yong; Pfeifer, Alexander; Kato, Hisashi; Shattil, Sanford; Boss, Gerry R; Pilz, Renate B.

Affiliation

Rangaswami H; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

Sci Signal ; 3(153): ra91, 2010 Dec 21.

Article in En | MEDLINE | ID: mdl-21177494

Subject(s)

Cyclic GMP-Dependent Protein Kinases/metabolism; Cyclic GMP/metabolism; Mechanotransduction, Cellular/physiology; Osteoblasts/physiology; Second Messenger Systems/physiology; src-Family Kinases/metabolism; Analysis of Variance; Animals; Biomechanical Phenomena; Bromodeoxyuridine; Cell Fractionation; Cell Line; Cell Proliferation; Cyclic GMP-Dependent Protein Kinases/genetics; Extracellular Signal-Regulated MAP Kinases/metabolism; Fluorescent Antibody Technique; Immunoblotting; Immunoprecipitation; Integrin beta Chains/metabolism; Mice; Mice, Knockout; Models, Biological; Nitric Oxide/metabolism; Osteoblasts/metabolism; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11/metabolism; Protein Tyrosine Phosphatase, Non-Receptor Type 6/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Stress, Mechanical

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoblasts / Second Messenger Systems / Cyclic GMP-Dependent Protein Kinases / Cyclic GMP / Src-Family Kinases / Mechanotransduction, Cellular Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2010 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google