Monitorization of drug content in furosemide and lorazepam tablets stored in multidose pill boxes.
J Pharm Bioallied Sci
; 2(4): 356-9, 2010 Oct.
Article
in En
| MEDLINE
| ID: mdl-21180472
ABSTRACT
BACKGROUND:
Therapeutic nonadherence is a major health problem, particularly when therapeutic regimens are complex and long-lasting. Therefore, tools such as multidose pill boxes have been designed to provide the means for higher therapeutic compliance. However, no studies are available reporting on their capacity to keep the drug content of the stored tablets unaltered.OBJECTIVE:
This work aimed at monitoring the drug content of tablets stored in multidose boxes for a period of two weeks. MATERIALS ANDMETHODS:
Furosemide and lorazepam were selected as model drugs, given their frequent chronic use, which is coherent with the profile of medicines susceptible of storage in the referred boxes. Variations of the tablets drug content were assessed as a function of temperature (25°C and 40°C) and the presence of blister. RESULTS ANDDISCUSSION:
The obtained results allowed concluding that concerning temperature, only lorazepam tablets registered drug content alterations and only when stored at 40°C. On the other side, it was concluded that the absence of blister does not compromise the drug content of the studied tablets.CONCLUSION:
In the specific conditions of this study, the storage of these medicines in multidose boxes is considered reliable and adequate.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Pharm Bioallied Sci
Year:
2010
Document type:
Article
Affiliation country:
Portugal