A human NK cell activation/inhibition threshold allows small changes in the target cell surface phenotype to dramatically alter susceptibility to NK cells.

Holmes, Tim D; El-Sherbiny, Yasser M; Davison, Adam; Clough, Sally L; Blair, G Eric; Cook, Graham P

Holmes, Tim D; El-Sherbiny, Yasser M; Davison, Adam; Clough, Sally L; Blair, G Eric; Cook, Graham P.

Affiliation

Holmes TD; Leeds Institute of Molecular Medicine, University of Leeds, St. James's University Hospital, Leeds LS9 7TF, United Kingdom.

J Immunol ; 186(3): 1538-45, 2011 Feb 01.

Article in En | MEDLINE | ID: mdl-21191066

Subject(s)

Cell Membrane/immunology; Genetic Predisposition to Disease/genetics; Killer Cells, Natural/immunology; Sarcoma, Ewing/immunology; Sarcoma, Ewing/metabolism; Tumor Escape/immunology; Cell Line, Tumor; Cell Membrane/genetics; Cell Membrane/pathology; Cytotoxicity Tests, Immunologic/methods; HeLa Cells; Humans; Immunity, Innate/genetics; Immunity, Innate/immunology; Immunophenotyping/methods; K562 Cells; Killer Cells, Natural/metabolism; Killer Cells, Natural/pathology; Lymphocyte Activation/immunology; NK Cell Lectin-Like Receptor Subfamily K/physiology; Sarcoma, Ewing/pathology; Spheroids, Cellular/immunology; Spheroids, Cellular/metabolism; Spheroids, Cellular/pathology; Translocation, Genetic/immunology; Tumor Cells, Cultured; Tumor Escape/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcoma, Ewing / Killer Cells, Natural / Cell Membrane / Tumor Escape / Genetic Predisposition to Disease Limits: Humans Language: En Journal: J Immunol Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United States

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