Embryonic pig pancreatic tissue for the treatment of diabetes: potential role of immune suppression with "off-the-shelf" third-party regulatory T cells.

Tchorsh-Yutsis, Dalit; Zlotnikov Klionsky, Yael; Bachar-Lustig, Esther; Aronovich, Anna; Feine, Ilan; Shezen, Elias; Rosen, Chava; Bitcover, Rivka; Eventov-Friedman, Smadar; Katchman, Helena; Zangi, Lior; Tal, Orna; Cohen, Sivan; Reisner, Yair

Tchorsh-Yutsis, Dalit; Zlotnikov Klionsky, Yael; Bachar-Lustig, Esther; Aronovich, Anna; Feine, Ilan; Shezen, Elias; Rosen, Chava; Bitcover, Rivka; Eventov-Friedman, Smadar; Katchman, Helena; Zangi, Lior; Tal, Orna; Cohen, Sivan; Reisner, Yair.

Affiliation

Tchorsh-Yutsis D; Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

Transplantation ; 91(4): 398-405, 2011 Feb 27.

Article in En | MEDLINE | ID: mdl-21192322

Subject(s)

Diabetes Mellitus/surgery; Pancreas Transplantation/immunology; Swine/immunology; T-Lymphocytes, Regulatory/immunology; Transplantation Tolerance; Transplantation, Heterologous/immunology; Animals; CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Embryo, Mammalian/immunology; Fingolimod Hydrochloride; Graft Survival/immunology; Immunosuppressive Agents/therapeutic use; Insulin/blood; Mice; Mice, Inbred C57BL; Propylene Glycols/therapeutic use; Sirolimus/therapeutic use; Sphingosine/analogs & derivatives; Sphingosine/therapeutic use; Swine/embryology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Swine / Transplantation, Heterologous / Pancreas Transplantation / T-Lymphocytes, Regulatory / Transplantation Tolerance / Diabetes Mellitus Type of study: Guideline Limits: Animals Language: En Journal: Transplantation Year: 2011 Document type: Article Affiliation country: Israel

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