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Oroidin inhibits the activity of the multidrug resistance target Pdr5p from yeast plasma membranes.
da Silva, Fernanda R; Tessis, Ana Claudia; Ferreira, Patricia F; Rangel, Luciana P; Garcia-Gomes, Aline S; Pereira, Fabio R; Berlinck, Roberto G S; Muricy, Guilherme; Ferreira-Pereira, Antonio.
Affiliation
  • da Silva FR; Laboratório de Bioquímica Microbiana, Departamento de Microbiologia Geral, IMPPG, Universidade Federal do Rio de Janeiro, CEP 21941-590, Rio de Janeiro, RJ, Brazil.
J Nat Prod ; 74(2): 279-82, 2011 Feb 25.
Article in En | MEDLINE | ID: mdl-21207971
Oroidin was isolated from the marine sponge Agelassventres and inhibited the activity and function of Pdr5p, an enzyme responsible for the multidrug resistance phenotype in Saccharomyces cerevisiae. This compound may help in the development of new drugs that reverse this dangerous phenotype of pathogenic yeast and fungi.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Saccharomyces cerevisiae / ATP-Binding Cassette Transporters / Saccharomyces cerevisiae Proteins Limits: Animals Language: En Journal: J Nat Prod Year: 2011 Document type: Article Affiliation country: Brazil Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrroles / Saccharomyces cerevisiae / ATP-Binding Cassette Transporters / Saccharomyces cerevisiae Proteins Limits: Animals Language: En Journal: J Nat Prod Year: 2011 Document type: Article Affiliation country: Brazil Country of publication: United States