Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.

Cuadrado-Tejedor, Mar; Ricobaraza, Ana; Del Río, Joaquín; Frechilla, Diana; Franco, Rafael; Pérez-Mediavilla, Alberto; Garcia-Osta, Ana

Cuadrado-Tejedor, Mar; Ricobaraza, Ana; Del Río, Joaquín; Frechilla, Diana; Franco, Rafael; Pérez-Mediavilla, Alberto; Garcia-Osta, Ana.

Affiliation

Cuadrado-Tejedor M; Division of Neurosciences, CIMA, University of Navarra, Avenida Pio XII 55, Pamplona, Spain. mcuadrado@unav.es

Behav Brain Res ; 220(2): 338-43, 2011 Jul 07.

Article in En | MEDLINE | ID: mdl-21238494

Subject(s)

Cognition Disorders/etiology; Cyclin-Dependent Kinase 5/metabolism; Stress, Psychological/complications; Stress, Psychological/metabolism; tau Proteins/metabolism; ADAM Proteins/metabolism; ADAM10 Protein; Amyloid Precursor Protein Secretases/metabolism; Amyloid beta-Protein Precursor/metabolism; Animals; Aspartic Acid Endopeptidases/metabolism; Avoidance Learning/physiology; DNA-Binding Proteins; Disease Models, Animal; Female; Hippocampus/metabolism; Maze Learning/physiology; Membrane Proteins/metabolism; Mice; Mice, Inbred C57BL; NFI Transcription Factors/metabolism; Phosphorylation/physiology; Polycomb-Group Proteins; Reaction Time/physiology; Serine/metabolism; Stress, Psychological/pathology; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Psychological / Tau Proteins / Cognition Disorders / Cyclin-Dependent Kinase 5 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Behav Brain Res Year: 2011 Document type: Article Affiliation country: Spain Country of publication: Netherlands

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