Preparation and characterization of ß-elemene-loaded microemulsion.
Drug Dev Ind Pharm
; 37(7): 765-74, 2011 Jul.
Article
in En
| MEDLINE
| ID: mdl-21244276
ABSTRACT
Intravenously injectable emulsion of ß-elemene was studied in detail. Both blank and ß-elemene-loaded microemulsions were prepared using a simple water titration method. The pseudoternary phase diagram was constructed for the optimization of microemulsion. The loading capacity test, dilutability test, and especially the influence of antioxidants were conducted for further optimization of ß-elemene-loaded microemulsion. Transmission electron microscope showed intact and spherical microemulsion droplets. Conductivity and viscosity measurements were used to study the phase behaviors of ß-elemene-loaded microemulsions, providing convincing explanation. In vitro release study showed that ß-elemene was steadily released until 12 h, which most fitted the first order.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sesquiterpenes
Limits:
Humans
Language:
En
Journal:
Drug Dev Ind Pharm
Year:
2011
Document type:
Article