AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.

Kuznetsov, Jeffim N; Leclerc, Guy J; Leclerc, Gilles M; Barredo, Julio C

Kuznetsov, Jeffim N; Leclerc, Guy J; Leclerc, Gilles M; Barredo, Julio C.

Affiliation

Kuznetsov JN; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 1580 NW 10 Ave, Miami, FL 33136, USA.

Mol Cancer Ther ; 10(3): 437-47, 2011 Mar.

Article in En | MEDLINE | ID: mdl-21262957

Subject(s)

AMP-Activated Protein Kinases/metabolism; Apoptosis; Endoplasmic Reticulum/metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Proto-Oncogene Proteins c-akt/metabolism; AMP-Activated Protein Kinases/antagonists & inhibitors; Aminoimidazole Carboxamide/analogs & derivatives; Aminoimidazole Carboxamide/pharmacology; Apoptosis/drug effects; Carbon/metabolism; Cell Line, Tumor/drug effects; Cell Proliferation; Drug Synergism; Endoplasmic Reticulum/drug effects; Endoplasmic Reticulum/genetics; Humans; Methotrexate/pharmacology; Molecular Targeted Therapy; Phosphorylation/drug effects; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Ribonucleotides/pharmacology; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Endoplasmic Reticulum / Proto-Oncogene Proteins c-akt / Precursor Cell Lymphoblastic Leukemia-Lymphoma / AMP-Activated Protein Kinases Limits: Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2011 Document type: Article Affiliation country: United States

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