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Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis.
Jurkin, Jennifer; Zupkovitz, Gordin; Lagger, Sabine; Grausenburger, Reinhard; Hagelkruys, Astrid; Kenner, Lukas; Seiser, Christian.
Affiliation
  • Jurkin J; Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Vienna, Austria.
Cell Cycle ; 10(3): 406-12, 2011 Feb 01.
Article in En | MEDLINE | ID: mdl-21270520
Histone deacetylases (HDACs) are negative regulators of gene expression and have been implicated in tumorigenesis and tumor progression. Therefore, HDACs are promising targets for anti-tumor drugs. However, the relevant isoforms of the 18 members encompassing HDAC family have not been identified. Studies utilizing either gene targeting or knockdown approaches reveal both specific and redundant functions of the closely related class I deacetylases HDAC1 and HDAC2 in the control of proliferation and differentiation. Combined ablation of HDAC1 and HDAC2 in different cell types led to a severe proliferation defects or enhanced apoptosis supporting the idea that both enzymes are relevant targets for tumor therapy. In a recent study on the role of HDAC1 in teratoma formation we have reported a novel and surprising function of HDAC1 in tumorigenesis. In this tumor model HDAC1 attenuates proliferation during teratoma formation. In the present work we discuss new findings on redundant and unique functions of HDAC1 and HDAC2 as regulators of proliferation and tumorigenesis and potential implications for applications of HDAC inhibitors as therapeutic drugs.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Proliferation / Histone Deacetylase 1 / Histone Deacetylase 2 / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Cycle Year: 2011 Document type: Article Affiliation country: Austria Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Proliferation / Histone Deacetylase 1 / Histone Deacetylase 2 / Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Cycle Year: 2011 Document type: Article Affiliation country: Austria Country of publication: United States