Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.

Nakanishi, Yasuharu; Matsushita, Akinori; Matsuno, Kiyomi; Iwasaki, Kazuhide; Utoh, Masahiro; Nakamura, Chika; Uno, Yasuhiro

Nakanishi, Yasuharu; Matsushita, Akinori; Matsuno, Kiyomi; Iwasaki, Kazuhide; Utoh, Masahiro; Nakamura, Chika; Uno, Yasuhiro.

Affiliation

Nakanishi Y; Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories, Ltd., Kainan, Japan.

Drug Metab Pharmacokinet ; 26(3): 288-94, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21273732

Subject(s)

Cytochrome P-450 Enzyme System/metabolism; Intestine, Small/enzymology; Liver/enzymology; Macaca fascicularis/metabolism; Pharmaceutical Preparations/metabolism; Animals; Aryl Hydrocarbon Hydroxylases/metabolism; Biocatalysis; Chlorzoxazone/metabolism; Cytochrome P-450 CYP1A1/metabolism; Cytochrome P-450 CYP2A6; Cytochrome P450 Family 2; Diclofenac/metabolism; Duodenum/enzymology; Ileum/enzymology; Jejunum/enzymology; Kinetics; Male; Mephenytoin/metabolism; Microsomes/enzymology; Microsomes, Liver/enzymology; Midazolam/metabolism; Mixed Function Oxygenases/metabolism; Paclitaxel/metabolism; Steroid 16-alpha-Hydroxylase/metabolism; Steroid Hydroxylases/metabolism; Tolbutamide/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Cytochrome P-450 Enzyme System / Intestine, Small / Liver / Macaca fascicularis Limits: Animals Language: En Journal: Drug Metab Pharmacokinet Journal subject: FARMACOLOGIA / METABOLISMO Year: 2011 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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