Strategies towards improving the pharmacokinetic profile of Îµ-substituted lysinol-derived HIV protease inhibitors.

Rajapakse, Hemaka A; Walji, Abbas M; Moore, Keith P; Zhu, Hong; Mitra, Aurpon W; Gregro, Alison R; Tinney, Elizabeth; Burlein, Christine; Touch, Sinoeun; Paton, Brenda L; Carroll, Steven S; DiStefano, Daniel J; Lai, Ming-Tain; Grobler, Jay A; Sanchez, Rosa I; Williams, Theresa M; Vacca, Joseph P; Nantermet, Philippe G

Rajapakse, Hemaka A; Walji, Abbas M; Moore, Keith P; Zhu, Hong; Mitra, Aurpon W; Gregro, Alison R; Tinney, Elizabeth; Burlein, Christine; Touch, Sinoeun; Paton, Brenda L; Carroll, Steven S; DiStefano, Daniel J; Lai, Ming-Tain; Grobler, Jay A; Sanchez, Rosa I; Williams, Theresa M; Vacca, Joseph P; Nantermet, Philippe G.

Affiliation

Rajapakse HA; Department of Medicinal Chemistry, Merck Research Laboratories, P. O. Box 4, West Point, PA 19486, USA. hemaka_rajapakse@merck.com

ChemMedChem ; 6(2): 253-7, 2011 Feb 07.

Article in En | MEDLINE | ID: mdl-21275047

Subject(s)

HIV Protease Inhibitors/pharmacokinetics; Lysine/chemistry; Antiretroviral Therapy, Highly Active; HIV Infections/drug therapy; HIV Protease Inhibitors/chemistry; HIV Protease Inhibitors/therapeutic use; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Protease Inhibitors / Lysine Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: Germany

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