Treatment of advanced non-small-cell lung cancer with Chinese herbal medicine by stages combined with chemotherapy.
J Cancer Res Clin Oncol
; 137(7): 1117-22, 2011 Jul.
Article
in En
| MEDLINE
| ID: mdl-21298288
ABSTRACT
PURPOSE:
To observe the effect of Chinese herbal medicine by stages combined with chemotherapy in treating patients with non-small-cell lung cancer (NSCLC) of stage III or IV.METHODS:
Adopting prospective, randomized, controlled, multi-centered trial design, 121 patients enrolled were assigned to the treatment group (n = 65) and the control group (n = 56). All the patients were randomized to receive chemotherapy alone or chemotherapy and Chinese herbal medicine combined (Kangliuzengxiao decoction during chemotherapy and Feiyanning decoction after chemotherapy). The main outcome measures were survival time, Karnofsky score, main clinical symptoms, and adverse reactions.RESULTS:
Five patients discontinued from the trial due to oral administration of Iressa after disease progression or other reasons, and 116 patients were evaluable for clinical efficacy with 63 in the treatment group and 53 in the control group. The overall response rate were 15.87% vs. 7.55% (P = 0.170), and the disease control rate were 85.71% vs. 71.70% in the treatment and control group (P = 0.063), respectively. The median survival time was 16.17 months vs. 12.00 months in the treatment and control group (P = 0.165), respectively. In addition, adverse reactions such as leucopenia in the treatment group were less than those in the control group (P = 0.039).CONCLUSIONS:
Chinese herbal medicine combined with chemotherapy showed favorable effect in improving quality of life and prolonging survival time on patients with advanced NSCLC.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
/
Carcinoma, Squamous Cell
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Adenocarcinoma
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Antineoplastic Combined Chemotherapy Protocols
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Carcinoma, Non-Small-Cell Lung
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Lung Neoplasms
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Aspects:
Patient_preference
Limits:
Adolescent
/
Adult
/
Aged
/
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
J Cancer Res Clin Oncol
Year:
2011
Document type:
Article
Affiliation country:
China