Discovery of ß-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.

Park, Woul Seong; Kang, Seung Kyu; Jun, Mi Ae; Shin, Mi Sik; Kim, Ki Young; Rhee, Sang Dal; Bae, Myung Ae; Kim, Min Sun; Kim, Kwang Rok; Kang, Nam Sook; Yoo, Sung-Eun; Lee, Jie Oh; Song, Dong Hyun; Silinski, Peter; Schneider, Stephen Edward; Ahn, Jin Hee; Kim, Sung Soo

Park, Woul Seong; Kang, Seung Kyu; Jun, Mi Ae; Shin, Mi Sik; Kim, Ki Young; Rhee, Sang Dal; Bae, Myung Ae; Kim, Min Sun; Kim, Kwang Rok; Kang, Nam Sook; Yoo, Sung-Eun; Lee, Jie Oh; Song, Dong Hyun; Silinski, Peter; Schneider, Stephen Edward; Ahn, Jin Hee; Kim, Sung Soo.

Affiliation

Park WS; Drug Discovery Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon, Republic of Korea.

Bioorg Med Chem Lett ; 21(5): 1366-70, 2011 Mar 01.

Article in En | MEDLINE | ID: mdl-21306895

Subject(s)

Dipeptidyl-Peptidase IV Inhibitors/chemical synthesis; Thiazolidines/chemical synthesis; Administration, Oral; Animals; Crystallography, X-Ray; Dipeptidyl-Peptidase IV Inhibitors/chemistry; Dipeptidyl-Peptidase IV Inhibitors/pharmacology; Disease Models, Animal; Dogs; Enzyme Activation/drug effects; Inhibitory Concentration 50; Molecular Structure; Rats; Thiazolidines/chemistry; Thiazolidines/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiazolidines / Dipeptidyl-Peptidase IV Inhibitors Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Country of publication: United kingdom

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