Carbon Dioxide/metabolism; Chemoreceptor Cells/physiology; Rett Syndrome/metabolism; Rett Syndrome/physiopathology; Action Potentials/drug effects; Action Potentials/physiology; Animals; Carbon Dioxide/pharmacology; Chemoreceptor Cells/drug effects; Desipramine/pharmacology; Desipramine/therapeutic use; Disease Models, Animal; Electric Impedance; Electrophysiological Phenomena/drug effects; Electrophysiological Phenomena/physiology; Female; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Hypercapnia/physiopathology; Locus Coeruleus/cytology; Locus Coeruleus/drug effects; Locus Coeruleus/physiopathology; Lung/physiopathology; Male; Membrane Potentials/drug effects; Membrane Potentials/physiology; Methyl-CpG-Binding Protein 2/genetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Norepinephrine/metabolism; Potassium Channels, Inwardly Rectifying/genetics; Potassium Channels, Inwardly Rectifying/metabolism; Rats; Respiration/drug effects; Respiration/genetics; Rett Syndrome/drug therapy; Rett Syndrome/genetics; Transfection; Up-Regulation/genetics; Kir5.1 Channel