Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: the OCEAN study.

Eastell, Richard; Nagase, Shinichi; Ohyama, Michiyo; Small, Maria; Sawyer, James; Boonen, Steven; Spector, Tim; Kuwayama, Tomohiro; Deacon, Steve

Eastell, Richard; Nagase, Shinichi; Ohyama, Michiyo; Small, Maria; Sawyer, James; Boonen, Steven; Spector, Tim; Kuwayama, Tomohiro; Deacon, Steve.

Affiliation

Eastell R; University of Sheffield, Sheffield, United Kingdom. r.eastell@sheffield.ac.uk

J Bone Miner Res ; 26(6): 1303-12, 2011 Jun.

Article in En | MEDLINE | ID: mdl-21312264

Subject(s)

Cathepsin K/antagonists & inhibitors; Enzyme Inhibitors/adverse effects; Enzyme Inhibitors/therapeutic use; Osteoporosis, Postmenopausal/drug therapy; Thiazolidines/adverse effects; Thiazolidines/therapeutic use; Biomarkers/blood; Biomarkers/urine; Bone Density/drug effects; Bone Remodeling/drug effects; Demography; Enzyme Inhibitors/pharmacology; Female; Humans; Osteoporosis, Postmenopausal/blood; Osteoporosis, Postmenopausal/physiopathology; Osteoporosis, Postmenopausal/urine; Thiazolidines/pharmacology; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis, Postmenopausal / Enzyme Inhibitors / Thiazolidines / Cathepsin K Type of study: Clinical_trials Limits: Female / Humans Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2011 Document type: Article Affiliation country: United kingdom Country of publication: United States

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