Novel methodologies for the synthesis of functionalized pyroglutamates.
Chem Commun (Camb)
; 47(11): 3219-21, 2011 Mar 21.
Article
in En
| MEDLINE
| ID: mdl-21318205
Alkylation of amino-acid derived iminoesters with Baylis-Hillman (BH) template based allyl bromides furnished α-methylene-ß-substituted-pyroglutamates, while the corresponding alkylation with BH derived allylic acetates provided α-alkylidene-pyroglutamates. These methodologies have been applied in the synthesis of fused [3.2.0]-γ-lactam-ß-lactones.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrrolidonecarboxylic Acid
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2011
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom