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Novel methodologies for the synthesis of functionalized pyroglutamates.
Tekkam, Srinivas; Alam, M A; Jonnalagadda, Subash C; Mereddy, Venkatram R.
Affiliation
  • Tekkam S; Department of Chemistry and Biochemistry, University of Minnesota Duluth, 1039 University Drive, Duluth, MN 55812, USA.
Chem Commun (Camb) ; 47(11): 3219-21, 2011 Mar 21.
Article in En | MEDLINE | ID: mdl-21318205
Alkylation of amino-acid derived iminoesters with Baylis-Hillman (BH) template based allyl bromides furnished α-methylene-ß-substituted-pyroglutamates, while the corresponding alkylation with BH derived allylic acetates provided α-alkylidene-pyroglutamates. These methodologies have been applied in the synthesis of fused [3.2.0]-γ-lactam-ß-lactones.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidonecarboxylic Acid Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrrolidonecarboxylic Acid Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United kingdom