Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose.

Gramer, Michael J; Eckblad, Jackie J; Donahue, Ruth; Brown, Joseph; Shultz, Carrie; Vickerman, Kent; Priem, Patrick; van den Bremer, Ewald T J; Gerritsen, Jolanda; van Berkel, Patrick H C

Gramer, Michael J; Eckblad, Jackie J; Donahue, Ruth; Brown, Joseph; Shultz, Carrie; Vickerman, Kent; Priem, Patrick; van den Bremer, Ewald T J; Gerritsen, Jolanda; van Berkel, Patrick H C.

Affiliation

Gramer MJ; Genmab MN, Inc., 9450 Winnetka Ave N, Brooklyn Park, Minnesota 55445, USA. m.gramer@genmab.com

Biotechnol Bioeng ; 108(7): 1591-602, 2011 Jul.

Article in En | MEDLINE | ID: mdl-21328321

Subject(s)

Antibodies/metabolism; Chlorides/metabolism; Galactose/metabolism; Manganese Compounds/metabolism; Uridine/metabolism; Animals; Bioreactors; CHO Cells; Cricetinae; Cricetulus; Culture Media/chemistry; Glycosylation; Recombinant Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Uridine / Chlorides / Manganese Compounds / Galactose / Antibodies Type of study: Observational_studies / Prognostic_studies Limits: Animals Language: En Journal: Biotechnol Bioeng Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States

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