High prevalence of oral human papillomavirus infection in Fanconi's anemia patients.
Oral Dis
; 17(6): 572-6, 2011 Sep.
Article
in En
| MEDLINE
| ID: mdl-21332606
ABSTRACT
BACKGROUND:
Fanconi's anemia (FA) is a rare recessive genetic disorder characterized by bone marrow failure, developmental and congenital abnormalities, which frequently evolves to aplastic anemia and neoplasias, primarily acute leukemia and head-neck carcinomas. Risk of malignancies increases after hematopoietic stem cell transplantation (HSCT), and the role of human papillomavirus (HPV) in FA carcinogenesis have been proposed.OBJECTIVE:
To investigate prevalence of oral HPV in FA patients without oral malignant lesions. MATERIALS ANDMETHODS:
After oral examination, 76 subjects without detectable oral malignant lesions were included and classified in four groups 20 FA submitted to HSCT (I), 22 FA not submitted to HSCT (II), 18 severe aplastic anemia (SAA) submitted to HSCT (III) and 16 healthy subjects (IV). Liquid-based cytology sampling, HPV screening by polymerase chain reaction and genotyping by reverse hybridization were performed.RESULTS:
The HPV detection rates were group I 35%, group II 27.3%, group III 38% and group IV 6.25%. Prevalence of high risk HPV types, mainly HPV16, was detected. Compared with control group, suggestions for increased likelihood of being HPV infected in SAA (OR = 9.55, 95% CI 1.01-125.41) and FA patients submitted to HSCT (OR = 8.08, 0.83-72.29) emerged.CONCLUSION:
Patients without oral malignant lesions submitted to HSCT, have high prevalence of oral HPV. HPV screening and close follow up should be considered in these patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomavirus Infections
/
Alphapapillomavirus
/
Fanconi Anemia
/
Mouth Diseases
Type of study:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Oral Dis
Journal subject:
ODONTOLOGIA
Year:
2011
Document type:
Article
Affiliation country:
Brazil