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Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.
Yang, Jingsong; Campobasso, Nino; Biju, Mangatt P; Fisher, Kelly; Pan, Xiao-Qing; Cottom, Josh; Galbraith, Sarah; Ho, Thau; Zhang, Hong; Hong, Xuan; Ward, Paris; Hofmann, Glenn; Siegfried, Brett; Zappacosta, Francesca; Washio, Yoshiaki; Cao, Ping; Qu, Junya; Bertrand, Sophie; Wang, Da-Yuan; Head, Martha S; Li, Hu; Moores, Sheri; Lai, Zhihong; Johanson, Kyung; Burton, George; Erickson-Miller, Connie; Simpson, Graham; Tummino, Peter; Copeland, Robert A; Oliff, Allen.
Affiliation
  • Yang J; Oncology Research and Development, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA. jingsong.2.yang@gsk.com
Chem Biol ; 18(2): 177-86, 2011 Feb 25.
Article in En | MEDLINE | ID: mdl-21338916
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Proto-Oncogene Proteins c-abl / Drug Discovery / Hydantoins Limits: Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Proto-Oncogene Proteins c-abl / Drug Discovery / Hydantoins Limits: Humans Language: En Journal: Chem Biol Journal subject: BIOLOGIA / BIOQUIMICA / QUIMICA Year: 2011 Document type: Article Affiliation country: United States Country of publication: United States