Molecular mechanisms of signalling specificity via phosphorelay pathways in Arabidopsis.
Curr Protein Pept Sci
; 12(2): 126-36, 2011 Mar.
Article
in En
| MEDLINE
| ID: mdl-21348845
ABSTRACT
Multistep phosphorelay (MSP) pathways mediate a wide spectrum of adaptive responses in plants, including hormonal and abiotic stress regulations. Recent genetic evidence suggests both partial redundancy and possible functional cross-talk on the one hand and a certain level of specificity on the other. Here, we discuss recent achievements improving our understanding of possible molecular mechanisms of specificity in MSP. We consider a certain evolutionary conservation of ancestral two-component signalling systems from bacteria in a process of molecular recognition that, as we have recently shown, could be applied also to a certain extent in the case of plant MSP. Furthermore, we discuss possible roles of kinase and phosphatase activities, kinetics of both these enzymatic reactions, and phosphorylation lifetime. We include also recent findings on the expression specificity of individual members of MSP pathways and, finally, based on our recent findings, we speculate about a possible role of magnesium in regulation of MSP pathways in plants. All these mechanisms could significantly influence specificity and signalling output of the MSP pathways.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Signal Transduction
/
Arabidopsis
/
Arabidopsis Proteins
Type of study:
Prognostic_studies
Language:
En
Journal:
Curr Protein Pept Sci
Journal subject:
BIOQUIMICA
Year:
2011
Document type:
Article
Affiliation country:
Czech Republic