Tiotropium inhibits pulmonary inflammation and remodelling in a guinea pig model of COPD.

Pera, T; Zuidhof, A; Valadas, J; Smit, M; Schoemaker, R G; Gosens, R; Maarsingh, H; Zaagsma, J; Meurs, H

Pera, T; Zuidhof, A; Valadas, J; Smit, M; Schoemaker, R G; Gosens, R; Maarsingh, H; Zaagsma, J; Meurs, H.

Affiliation

Pera T; Department of Molecular Pharmacology, University Centre for Pharmacy, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands. t.pera@rug.nl

Eur Respir J ; 38(4): 789-96, 2011 Oct.

Article in En | MEDLINE | ID: mdl-21349917

Subject(s)

Airway Remodeling/drug effects; Cholinergic Antagonists/pharmacology; Pneumonia/drug therapy; Pulmonary Disease, Chronic Obstructive/drug therapy; Scopolamine Derivatives/pharmacology; Acetylcholine/physiology; Airway Remodeling/immunology; Animals; Animals, Outbred Strains; Disease Models, Animal; Emphysema/drug therapy; Emphysema/immunology; Goblet Cells/drug effects; Goblet Cells/immunology; Goblet Cells/metabolism; Guinea Pigs; Lipopolysaccharides/toxicity; Lung/drug effects; Lung/immunology; Male; Mucin 5AC/metabolism; Muscarinic Antagonists/pharmacology; Neutrophils/drug effects; Neutrophils/immunology; Pneumonia/immunology; Pulmonary Disease, Chronic Obstructive/immunology; Pulmonary Fibrosis/drug therapy; Pulmonary Fibrosis/immunology; Tiotropium Bromide

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Scopolamine Derivatives / Cholinergic Antagonists / Pulmonary Disease, Chronic Obstructive / Airway Remodeling Limits: Animals Language: En Journal: Eur Respir J Year: 2011 Document type: Article Affiliation country: Netherlands

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