The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease.

Wang, Lijian; Trebicka, Estela; Fu, Ying; Ellenbogen, Shiri; Hong, Charles C; Babitt, Jodie L; Lin, Herbert Y; Cherayil, Bobby J

Wang, Lijian; Trebicka, Estela; Fu, Ying; Ellenbogen, Shiri; Hong, Charles C; Babitt, Jodie L; Lin, Herbert Y; Cherayil, Bobby J.

Affiliation

Wang L; Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, USA.

Inflamm Bowel Dis ; 18(1): 112-9, 2012 Jan.

Article in En | MEDLINE | ID: mdl-21351217

Subject(s)

Anti-Bacterial Agents/metabolism; Antimicrobial Cationic Peptides/metabolism; Bone Morphogenetic Protein 6/metabolism; Colitis/pathology; Inflammatory Bowel Diseases/pathology; Animals; Anti-Bacterial Agents/antagonists & inhibitors; Antimicrobial Cationic Peptides/antagonists & inhibitors; Antimicrobial Cationic Peptides/genetics; Blotting, Western; Bone Morphogenetic Protein 6/antagonists & inhibitors; Bone Morphogenetic Protein 6/genetics; Colitis/etiology; Colitis/metabolism; Hepcidins; Inflammatory Bowel Diseases/metabolism; Interleukin-6/metabolism; Iron/blood; Male; Mice; Mice, Inbred C57BL; Pyrazoles/pharmacology; Pyrimidines/pharmacology; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Signal Transduction; T-Lymphocytes/transplantation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Colitis / Antimicrobial Cationic Peptides / Bone Morphogenetic Protein 6 / Anti-Bacterial Agents Type of study: Etiology_studies Limits: Animals Language: En Journal: Inflamm Bowel Dis Journal subject: GASTROENTEROLOGIA Year: 2012 Document type: Article Affiliation country: United States Country of publication: United kingdom

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