Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria.

Wirawan, E; Vande Walle, L; Kersse, K; Cornelis, S; Claerhout, S; Vanoverberghe, I; Roelandt, R; De Rycke, R; Verspurten, J; Declercq, W; Agostinis, P; Vanden Berghe, T; Lippens, S; Vandenabeele, P

Wirawan, E; Vande Walle, L; Kersse, K; Cornelis, S; Claerhout, S; Vanoverberghe, I; Roelandt, R; De Rycke, R; Verspurten, J; Declercq, W; Agostinis, P; Vanden Berghe, T; Lippens, S; Vandenabeele, P.

Affiliation

Wirawan E; VIB, Department for Molecular Biomedical Research, Ghent, Belgium.

Cell Death Dis ; 1: e18, 2010.

Article in En | MEDLINE | ID: mdl-21364619

Subject(s)

Apoptosis Regulatory Proteins/metabolism; Apoptosis; Autophagy; Caspases/metabolism; Membrane Proteins/metabolism; Mitochondria/metabolism; Amino Acid Sequence; Animals; Apoptosis Regulatory Proteins/analysis; Apoptosis Regulatory Proteins/genetics; Beclin-1; Cell Line; Humans; Interleukin-3/genetics; Interleukin-3/metabolism; Membrane Proteins/analysis; Membrane Proteins/genetics; Mice; Phosphatidylinositol 3-Kinases/genetics; Phosphatidylinositol 3-Kinases/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Apoptosis / Caspases / Apoptosis Regulatory Proteins / Membrane Proteins / Mitochondria Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Death Dis Year: 2010 Document type: Article Affiliation country: Belgium

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